Mustn't be afraid to dream a little bigger, darling.
May your journeys be fruitful and forgiving.

May you always find a reason to endure the darkest nights.

Life always surprises you with the most beautiful sunrises.

just-a-demon-butler:

RULE TIME! 

YOU DO NOT NEED TO BE FOLLOWING ME. 

REBLOG AS MANY TIMES AS YOU WISH.

FEEL FREE TO ASK QUESTIONS! 

IF YOU DO NOT WISH FOR A DRESS! That is a-okay! I will pay for a cosplay of your liking as long as it’s under 200 USD! You will still receive a headband, tea (of your liking) and a tea set! 

If you would like a closer look at the sites that I’ll be purchasing from! 

THE DRESSES / HEADBANDS / TEA / TEA SET

GIVEAWAY WILL END AUGUST 1ST! IF YOU ARE UNDER 18 I MUST HAVE SOME FORM OF PERMISSION FROM YOUR GUARDIAN(S)!

The desired dress of choice will take awhile to make so please keep that in mind! Thank you!  






neurosciencestuff:

Discovery of New Drug Targets for Memory Impairment in Alzheimer’s Disease

We are now a step closer to having a drug that can cure dementia and memory loss. Research team in Korea has discovered that reactive astrocytes, which have been commonly observed in Alzheimer’s patients, aberrantly and abundantly produce the chief inhibitory neurotransmitter GABA and release it through the Best1 channel. The released GABA strongly inhibits neighboring neurons to cause impairment in synaptic transmission, plasticity and memory. This discovery will open a new chapter in the development of new drugs for treating such diseases.

Alzheimer’s disease, which is the most common cause of dementia, is fatal and currently, there is no cure. In Alzheimer’s disease, brain cells are damaged and destroyed, leading to devastating memory loss. It is reported that 1 in 8 Americans aged 65 or over have Alzheimer’s disease. In 2011, 7,600 elderly people with dementia lost their way back home and became homeless in Korea. However, to date, there has been no clear understanding of the mechanisms underlying dementia in Alzheimer’s disease. So far, neuronal death is the only proposed mechanism available in scientific literature.

The research team discovered that reactive astrocytes in the brains of Alzheimer’s disease model mice produce the inhibitory transmitter GABA by the enzyme Monoamine oxidase B(MAO-B) and release GABA through the Bestrophin-1 channel to suppress normal information flow during synaptic transmission. Based on this discovery, the team was able to reduce the production and release of GABA by inhibiting MAO-B or Bestrophin-1, and successfully ameliorate impairments in neuronal firing, synaptic transmission and memory in Alzheimer’s disease model mice.

In the behavioral test, the team used the fact that mice tend to prefer dark places. If a mouse experiences an electric shock in a dark place, it will remember this event and avoid dark places from then on. However, a mouse with modeled Alzheimer’s disease cannot remember if such shock is related to dark places and keeps going back to dark places. The team demonstrated that treating these mice with a MAO-B inhibitor fully recovered the mice’s memory. The selegiline is currently used in Parkinson’s disease as an adjunct therapy and considered as a one of best promising medicine for MAO-B inhibitor. But it has been previously shown to be less effective in Alzheimer’s disease.

The team proved that selegiline is effective for a short time, but when it is used in long term, it loses its efficacy in Alzheimer’s disease model mice. When treated for 1 week, selegiline brought the neuronal firing to a normal level. But when it was treated for 2 and 4 weeks, neuronal firing came back to the levels of untreated mice. From these results, the team proposed that there is a pressing need for a new drug that has long lasting effects.

Dr. C. Justin Lee said, “From this study, we reveal the novel mechanism of how Alzheimer’s patients might lose their memory. We also propose new therapeutic targets, which include GABA production and release mechanisms in reactive astrocytes for treatment of Alzheimer’s disease. Furthermore, we provide a stepping stone for the development of MAO-B inhibitors with long lasting efficacy.”






A kitten aboard a floating Victoria water lily pad in the Philippines, 1935. Photograph by Alfred T. Palmer, National Geographic Creative.








stephandthejitters:

THIS IS A RANDOM POST TO REMIND YOU THAT YOU ARE A BEAUTIFUL EXPRESSION OF A HUMAN AND YOU HAVE EVERY REASON TO BE PROUD OF YOURSELF AND THERE ARE SO MANY PEOPLE OUT THERE THAT THINK OF A MEMORY OF YOU AND CAN’T HELP BUT SMILE AND I HOPE THAT YOU ARE EXCITED FOR SOME ASPECT OF YOUR DAY TODAY BECAUSE YOU DESERVE TO BE FULFILLED AND HAPPY THAT IS ALL THANK YOU



WORK, BITCH // clint barton’s workout mix, probably

inspired by this text post

i. work bitch- britney spears | ii. fergalicious- fergie | iii. eye of the tiger- survivor | iv. hips don’t lie- shakira ft wyclef jean | v. best song ever (kat krazy remix)- one direction | vi. boss ass bitch- nicki minaj | vii. timber- ke$ha ft pitbull | viii. my humps- the black eyed peas | ix. i will survive- gloria gaynor | x.partition- beyonce | xi. crazy in love- beyonce ft jay z | xi. do my thang- miley cyrus

[listen]